Abstract 17476: Optimal Predictors for Periprocedural Bleeding Events After Catheter Ablation for Atrial Fibrillation - Comparison of Total Thrombus-Formation Analysis System (T-TAS) and Plasma DOACs Concentration-

Introduction: Direct oral anticoagulants (DOACs) are mainly used in the prevention of thromboembolic complications in patients with atrial fibrillation (AF) and in the treatment of venous thromboembolism. As compared with warfarin, although routine monitoring is not required in therapeutic decision of DOACs, monitoring plasma DOACs concentration is important in specific clinical setting. Recently, we demonstrated that Total Thrombus-formation Analysis System (T-TAS) might be a useful tool in monitoring anticoagulant effects of direct oral anticoagulants and a predictor of bleeding events in AF patients undergoing radiofrequency catheter ablation (CA). Hypothesis: In this study, we evaluated the usefulness of T-TAS for predicting bleeding risk by comparing with plasma DOACs concentration. Methods: After exclusion of 107 from 212 consecutive patients, the remaining 105 consecutive patients underwent CA for AF treated with DOACs [dabigatran (n=19), rivaroxaban (n=54), and apixaban (n=32)] were enrolled at ou...