Investigation of the effect of Lactobacillus paracasei TD3 on cutaneous wound healing and induction of angiogenesis on male Wistar rats

Skin plays an essential role in the prevention of pathogenic microorganisms entrance. It is also considered as the first line of immune defense in our body. The therapeutic effects of probiotics on wound healing are well reported over the past decade. Nevertheless, there are limited publications about the impact of probiotics on skin wound healing. Here we assessed the effect of Lactobacillus paracasei TD3 on cutaneous wound healing in male Wistar rats. During this research, thirty-six male Wistar rats grouped into control positive, control negative, and trial groups, then the skins of rats were incised to make a full-thickness wound. An ointment produced from probiotic L. paracasei TD3 was administrated to the trial group, and immunohistological factors of each host were evaluated and compared with control groups. The final results showed that although L. paracasei TD3 could proceed the wound closure earlier than other groups and could induce angiogenesis in trial group, it could not cause any significant changes in the levels of monocytes, lymphocyte, mast cells and polymorphonuclear leukocytes in the trial group compared to control groups. This probiotic bacterium may be effective besides other probiotic bacteria.