Clinic analysis of opportunistic lung infections in patients with application of corticosteroids and immunosuppressive drugs for their renal diseases.

Objective To learn characteristic of opportunistic lung infections in patients treated with concomitant application of immunosuppressive drugs and corticosteroids for their renal diseases.Methods Retrospectively study clinic data of 11 patients who acquired opportunistic lung infections when they accepted concomitant treatment of immunosuppressive drugs and corticosteroids in oder to relieve renal diseases.Results Gradual dyspneas were main symptoms of patients,which happened after 8 weeks' application of immunosuppressive drugs and corticosteroids.Respiratory failure happened in 5 patients.Computerized tomography examination showed focal or diffuse infitration patch or ground glass opacification which distributed in bilateral lung fields.Serum cytomegalovirus(CMV) IgM antibody of one patient was positive,and aspergillus fumigatus was found in another patient's sputum culture.No evidence of microorganism was found in other patients.Antivirus and/or antifungus drugs were applied for treatment.Mechanical ventilations were applied when necessary.Finally all patients survived except two.Their lung functions recovered within 1 to 12 months.Conclusion Opportunistic lung infections may happen after application of immunosuppressive drugs and corticosteroids in patients with renal disease.Early diagnosis and treatment will improve patients' survival rate.