Clinical significance of the size of the necrotic area and the rate of its formation in the acute period of myocardial infarct

: The authors suggest a new method of interpreting the kinetics of the isoenzyme MB CPK in the body based on mathematical modelling. This method have made it possible to increase the accuracy of determining the necrotic size and to calculate the temporal parameters (rate and acceleration) of the formation of the necrotic focus. The studies have shown that these temporal parameters allow the timely (within the first 10-12 h of the disease) objective and quantitative assessment of the disease severity. The proposed method of interpretation was used in the biochemical examinations of 128 patients with acute myocardial infarction and the results obtained indicate its clinical-diagnostic and prognostic value.