Changes in antioxidative activity and composition of blood erythrocyte phospholipids induced in neurotic patients by phenazepam

Exposure of experimental animals and man to various stressor influences gives rise to intensification of free-radical lipid peroxidation (LPO) of cell membranes [4, 9]. The intensity of LPO is interconnected with the physicochemical properties of membrane lipids [3] and with functional activity of proteins, including enzymes, receptors, and channelforming units, dependent O n them. Considering the importance of emotional stress in the genesis and development of neurotic disorders, it can be tentatively suggested that a definite role in their pathogenesis is played by changes in peroxidation processes.