Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.

Abstract Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), the positive control. Control activities in male rats exceeded those in females by about 2–3 fold.