Two New Flavonoids fromDerris eriocarpaHow

Two new flavonoids, 1 and 2, together with two known flavonoids, tephrosin (3) and 12a-hydroxy-α-toxicarol (4), were isolated from the whole herb of Derris eriocarpa How. The structures and absolute configurations of the new compounds were elucidated on the basis of their MS, NMR, and ECD data. The structures of the known compounds were established by extensive spectroscopic (MS, 1D- and 2D-NMR) analyses and comparison with the literature data. All compounds were isolated from D. eriocarpa for the first time. Compound 3 showed modest inhibitory activities against the growth of human cancer cells HEL and A549 with the IC50 values of 15.03 ± 0.62 and 13.27 ± 0.39 μm, respectively.