[Changes in the rate of protein biosynthesis in the organs of mice under the action of the delta sleep-inducing peptide and psychoemotional stress].

: The effects of delta-sleep-inducing peptide (DSIP) and its analogs (ID-6 and ID-12) on the protein synthesis rate in the mouse brain, liver, and spleen were studied with special reference to mechanisms underlying the adaptogenic action of DSIP. Time-related changes of the protein synthesis rate were estimated in the mouse organs after a single intraperitoneal injection of the peptide (120 mg/kg body weight) and the psycho-emotional stress with or without preliminary (1 h before) injection of the peptide. After DSIP administration, the protein biosynthesis was activated and the dynamics of stress-induced changes of biosynthesis were modified. The data obtained suggest that the mechanisms underlying the DSIP adaptogenic action involve its modulatory effect on the regulatory system of protein biosynthesis.