Evaluation of post-conditioning effects of morphine sulfate on Corrected TIMI frame count in patients with anterior ST-segment myocardial infarction who have undergone primary PCI on the left anterior descending artery

Introduction: Corrected TIMI Frame Count (CTFC) is a predictor of cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI). This study evaluated the post-conditioning effects of morphine on CTFC in the patients undergoing primary precutanous coronary intervention (PPCI) on left anterior descending artery (LAD). Subjects & Methods: This cross-sectional study was conducted on 40 patients with STEMI undergoing PPCI on LAD. Based on receiving or not receiving of 5-milligram morphine 30 minutes before PCI, patients allocated to two groups (sequentially 14 and 26 patients). Results: There was no significant difference between two groups considering of age, sex, coronary risk factor and pre-PCI CTFC. However, post-PCI CTFC, was lower in the morphine group (13.23±4.84 versus 13.10±6.80 in control group; P= 0.000). In both groups, a significant reduction observed in CTFC after PCI, which was more in morphine group (morphine versus control: 24.95±19.04 versus 24.32±19.05; P = 0.787) but not statistically significant. Conclusion: According to the findings of this study, it seems that in elective surgery, the replacement of crystalloids ringer and ringer's lactate, there is a significant difference in PH and postoperative complications following the use of these serums. The blood acidity following fluid therapy with ringer was higher in comparison to fluid therapy with ringer's lactate, and the delay in awakening in this group was reported high.