Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

Atsushi Nakamura,Minoru Narita,Kan Miyoshi,Keiko Shindo,Daiki Okutsu,Masami Suzuki,Kimio Higashiyama,Tsutomu Suzuki

Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

2008

Atsushi Nakamura
Minoru Narita
Kan Miyoshi
Keiko Shindo
Daiki Okutsu
Masami Suzuki
Kimio Higashiyama
Tsutomu Suzuki

Introduction The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state.

Keywords:

Anesthesia
Internal medicine
Endocrinology
Psychology
Metabolite
Sciatic nerve
Active metabolite
Tramadol
Opioid receptor
Sciatic nerve injury
Analgesic
Neuropathic pain

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