MP25-02 INTRAOPERATIVE MOLECULAR IMAGING CAN IDENTIFY THORACIC RENAL CELL CARCINOMA METASTASES

INTRODUCTION AND OBJECTIVES:Patients with renal cell carcinoma (RCC) commonly develop metastatic disease, and 5-year survival in patients with untreated metastases is poor. The lungs are the second most common site of RCC metastases, and pulmonary metastasectomy can more than double 5-year survival in these patients. Intraoperative molecular imaging (IMI) has been used to identify thoracic metastases for a variety of primary tumors, including colorectal cancer and osteosarcomas. Here we describe our findings from clinical trials utilizing three different fluorescent dyes and their ability to identify thoracic RCC metastases: EC17, which fluoresces in the visible spectrum, and ICG and OTL38, which both fluoresce in the near-infrared region (NIR).METHODS:All studies were approved by our institution's Institutional Review Board and all patients gave informed consent. Patients received one of three dyes: EC17, ICG, or OTL38. Depending on the dye infused, patients were infused between 4 and 24 hours prior to s...