Protein isolation methods from production cell

The present invention includes a method of destroying biological cells using a homogenizer device, the device is an orifice plate with an orifice plate and at least one outlet nozzle with at least one inlet nozzle (a), in the intermediate space between the orifice plate together, a static mixer is installed, and optionally, the orifice plate and the baffle plate with mechanical energy or be introduced additionally or (b) at least one inlet nozzle wherein the in the intermediate gap between the orifice plate and the baffle plate, as appropriate, a static mixer is installed, and / or mechanical energy is introduced. .BACKGROUND