4- {4-[({[4-Chloro-3- (trifluoromethyl) phenyl] amino} carbonyl) amino] phenoxy} -N-methylpyridine-2-carboxamide

The present invention relates to 4- {4-[({[4-chloro-3- (trifluoromethyl) phenyl] amino} carbonyl) amino] phenoxy} -N-methylpyridine-2-carboxamide and its tosylate salt, With regard to the process for the preparation of (I), it is the first stage that a compound of formula (V) is initially placed in a non-chlorinated organic solvent inert to isocyanates at a temperature of 20 ° C. to 60 ° C. The compound of formula (V) is reacted with 4-chloro-3-trifluoromethylphenylisocyanate by mixing with -3-trifluoromethylphenylisocyanate so that the reaction temperature does not exceed 70 ° C. In the second stage, the compound of formula (II) in p-toluenesulfonic acid and polar solvent at a reaction temperature from 40 ° C. to the reflux temperature of the solvent used. Including that case. [Chemical 1]