Состояние антиоксидантной активности крови при геморрагическом шоке в эксперименте

Objectives. To study in experiment the anti-and prooxidant blood properties in healthy laboratory animals and when they are in the condition of hemorrhagic shock. Materials and methods. During the experiment, the laboratory animals were divided into two groups. The first group (control) included healthy white rats. The second group (experimental) consisted of the animals modeled to be in hemorrhagic shock. The status of anti-and prooxidant blood properties as well as glucose and blood urea concen-tration, red blood characteristics of the animals from both the groups was determined. Morphological study of the animals from the second group was carried out. Results. In the first group, the blood of the animals had antioxidant properties. The animals in the state of he-morrhagic shock observed prooxidant activity of the blood with the development of oxidative stress. In acute mas-sive loss of blood the cellular homeostasis became inferior with the progression of multiple organ failure and course aggravation of hemorrhagic shock. Conclusion. Acute massive loss of blood leads to hemorrhagic shock, free radical imbalance with the formation of oxidative stress. Early inclusion of antioxidant drugs in the complex therapy may improve the course of he-morrhagic shock in patients with acute severe loss of blood.