EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS

Introduction:Minocycline is a derivative of tetracycline that has anti -inflammatory, antiappoptic, antioxidant and neuroprotective effects. Since there is a relationship between cell d eath and seizure, the aim of this study was to examine the role of minocycline in development of amygdala kindling in Wistar rats. Methods:In this study, 21 rats were divided into three groups. After sterotaxic surgery and 1 week recovery period, rats received kindling stimulations (twice daily at 6 hour intervals). Group 1 (n=7) received daily kindling stimulations. Groups 2 (n=7) and 3(n=7) received saline (1 ml/kg) and minocycline (25 mg/kg), respectively, 60 min before kindling stimulation.CumulativeAfterdischarge Duration (ADD), Cumulative Seizure duration (SD) and Seizure Stage (SS) were recorded and compared to the control group. Results:In group 3, intraperitoneal administration of minocycline for 10 days significantly reduced cumulative ADD (control group: 907.2±64.5, minocycline group: 717.8±67.9) (F (18, 216)=3.5, p<0.001) �� and cumulative SD (control