Postoperative Leukocytosis After Robotic-Assisted Radical Prostatectomy Is Not Associated with Perioperative Outcome and Histopathological Findings

Abstract Introduction: Recently a retrospective study has been published describing a significant correlation of immediate postoperative leukocytosis (IPLC) and a favorable pathological Gleason score (pGS) in patients undergoing robotic-assisted radical prostatectomy (RARP). The aim of the present study was to prospectively validate these results on an external dataset. Materials and Methods: In total, 346 patients undergoing RARP as first-line therapy for localized prostate cancer were included. Clinical and histopathological parameters, criteria of IPLC, and pGS were recorded prospectively. Potential association between IPLC and pGS was evaluated by univariate and multivariate analyses. Results: IPLC was found in 77.2% (n = 267) of all patients with a median leukocyte blood count (LBC) of 12.5 × 109/L (interquartile range, 10.2–15 × 109/L). Of these, in 255 patients IPLC was found within the range of 10–20 × 109/L, whereas an IPLC of >20 × 109/L was found in only 12 patients. Of the patients, 49.1%, 40....