Cis form-3- (tert butoxycarbonylamino) naphthenic acid preparing method
2016
The invention discloses a method for preparing cis form -3- (tert butoxycarbonylamino) naphthenic acid with the steps of putting m-aminobenzoic acid, catalysts and solvents into the high-pressure reaction kettle and obtaining cis-trans mixed m-aminonaphthenic acid through high-pressure hydrogenation; then putting the m-aminonaphthenic acid into the solvents, adding certain sodium alkoxide as the catalyst and obtaining the m-aminonaphthenic acid with the content exceeding 90% after temperature rise and backflow through isomerization reaction; protecting amidogen by BOC and finally obtaining pure cis form -3- (tert butoxycarbonylamino) naphthenic acid through dichloromethane and petroleum ether recrystallization. Beneficial effects of the invention: the invention provides a method for preparing the cis form -3- (tert butoxycarbonylamino) naphthenic acid with raw materials easy to get and for mass production and cost largely reduced.
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