Abstract 12717: If Channel Blocker Ivabradine Counteracts Underisable Tachycardia in Patients Supported With Inotropic Agents

Introduction: The utilization of inotropic agents is usually linked to development of unappropriated and undesirable sinus tachycardia. That use also increases the myocardial oxygen consumption, could develop ischemic events and also has pro arrhythmic effects in coronary patients with acute heart failure, existing limited therapeutic options to face that situation. Hypothesis: The If channels blocker Ivabradine could be useful and safe for counteract the sinus tachycardia induced by inotropic agents and its undesirable effects without affecting the positive inotropic effect. Methods: Patients with ischemic-necrotic cardiomyopathy and low ejection fraction (under 35%) admitted for acute decompensation of heart failure with requirement of inotropic agents were prospectively and consecutively included. Patients with a rhythm different than sinus rhythm, impossibility for place a Swan-Ganz catheter or unable to use the oral route were excluded. Hemodynamic measurements with Pulmonary Artery catheters were pe...