Новые лекарственные препараты для офтальмологии на основе 6-метил-3-(тиетан-3-ил)урацила (экспериментальное исследование)

Purpose : develop of new drugs for ophthalmology based on 6-methyl-3-(thietan-3-yl)uracil and methyluracil. Materials and methods . An experimental study was carried out on 10 rabbits with a body weight of 3.5–4.0 kg of chinchilla breed. A thermal burn of the cornea in the eyes of 6 rabbits and a chemical burn of the cornea in the eyes of 4 rabbits were modeled. Therapy with the use of drugs was carried out: ophthalmic ointment — in thermal burns, ophthalmic medicinal films based on 6-methyl-3-(thietan-3-yl)uracil and methyluracil in chemical burns. Results . The use of ophthalmic ointment based on 6-methyl-3-(thietan-3-yl)uracil for thermal burns led to a decrease in conjunctival hyperemia and resorption of corneal edema by 4–5 days. On the 14th day of therapy, the microscopic picture of the rabbits cornea had the usual normal structure. The use of 6-methyl-3-(thietan-3-yl)uracil and methyluracil based ophthalmic drug films yielded the following results: centripetal epithelialization of corneal erosion was observed, epithelial regeneration was higher with the use of methyluracil eye drug films and total epithelization was achieved on the 7th day of observation than when using eye drug films based on 6-methyl-3-(thietan-3-yl)uracil, where total epithelization occurred on the 14th day. Complete restoration of the surface epithelial layer of the cornea in both groups was observed on the 21st day. Conclusions . The use of new drugs based on 6-methyl-3-(thietan-3-yl)uracil and methyluracil in various types of corneal burns showed good tolerance in the eyes of experimental animals, shortened the treatment time, and achieved high wound healing efficacy.