Effects of propofol on spontaneous motor activity and learning behaviors in juvenile mice

Aim To investigate the effects of propofol(prof) on spontaneous motor activity and learning behaviors and to explore their relationships with GABAA receptor in juvenile mice.Methods Three hundred mice were divided into three main groups for three experiments.Each group was subdivided into ten subgroups:normal control,Prof 25,50,100 mg·kg-1,Bic 0.05,0.1,0.2 μg,and Prof 100 mg·kg-1+Bic 0.05,0.1,0.2 μg.Prof was ip given 10 min before Bic icv given.Locomotor activities in 15,30,45 and 60 min after given Bic were recorded and the latency and error number of step down and step through test in 1d and 2d were detected.Results Compared with NS group,Prof decreased the locomotor activities,and the latency and increased the error number of step down and step through tests in juvenile mice.Bic didn′t affect the locomotor activities,the latency and the error number of step down and step through tests in juvenile mice.But Bic decreased the effect of Prof on locomotor activities,the latency and error number of step down and step through tests in juvenile mice.Conclusion Propofol can decrease the locomotor activities and restrain learning and memory function in juvenile mice,and GABAA receptor may be involved in the effects.