Method for producing a concentrate of high purity vii active factor essentially free of vitamin K factors addicts and VIIIc and viiicag factors.

The invention relates to a method for manufacturing a concentrate of factor VII high-purity activated. This method comprises the use of a cryoprecipitate-depleted plasma, preferably of human origin and at least one purification step at least one chromatography on ion exchange resin and that a step of activating the factor VII, characterized in that firstly performs the direct activation of factor VII in the crude plasma cryoprecipitate-free supernatant, without the addition of exogenous proteins. Thanks to the invention, the activated factor VII of high purity and substantially free of vitamin K factors depen dent and VIIIC and VIIICAg factors and has a ratio factor VIIa / factor VII greater than 5 with a specific activity of activated factor VII than 200 IU / mg protein.