A tobacco smoke tobacco products and non-volatile nitrosamines n- gc-ms / ms analysis Determination

A tobacco smoke tobacco products and non-volatile nitrosamines N- GC-MS / MS analysis measurement method, comprising: after the sample is ground into a powder tobacco or tobacco-free flue gas sample, accurately weighed, internal standard was added methylene chloride and an alkaline solution, and shaken on a shaker, was added anhydrous magnesium sulfate, hand shaken, then N- propyl-ethylenediamine (PSA) and carbon graphite, hand mixed by shaking again uniform; then shaken, centrifuged and the supernatant was concentrated nitrogen blowing, and finally determined by GC-MS / MS. Advantage of the present invention is that: the first matrix dispersion is introduced into the solid phase extraction method without pre-treatment of tobacco and tobacco smoke N- volatile nitrosamines in order to achieve the purification of the substrate, which pre-treatment method is simple, sample analysis little interference, high sensitivity, and good reproducibility, provide technical support for accurate assessment of security risk tobacco and tobacco smoke without N- volatile nitrosamines.