Perbedaan Agregasi Trombosit pada Penderita yang Mendapat Propofol dan Penthotal

Background : Perioperative bleeding is a serious and common problem in surgery. Some induction anesthetic agents are thought to inhibit platelet aggregation. The propofol and penthotal had effect on platelet aggregation. Objective : Determine the difference effects of propofol and penthotal administration on platelet aggregation. Method : An Randomized Clinical Control Trial study on 34 patients who received general anesthesia, divided into two groups (n: 17). Both groups received Propofol or Penthotal were examined TAT before and five minutes after induction All data were analyzed by pair t -test and independent t-test for Propofol or Penthotal and platelet aggregation. Result : Maximal platelet aggregation before and after the administration of propofol and penthotal is significant, difference. In propofol and penthotal group, the percentage of maximal platelet aggregation was 54,93±9,38 and 66,26±8,94 (p=0,0001). We found 64,71% hypoaggregation, 17,65% mild hypo aggregation and 17,65% normo aggregation on propofol group, and 11,76% of hypo aggregation, 23,53% mild hypoaggregation and 64,71% normoaggregation on penthotal group. Statistically, propofol caused significant hypoaggregation of platelet compared to penthotal). Conclusion : Propofol significantly lowers the percentage of maximal platelet aggregation and causes more hypoaggregation than penthotal. Keywords : propofol, penthotal, ADP, platelet aggregation ABSTRAK Latar belakang : Perdarahan perioperatif merupakan masalah yang sering dihadapi dalam setiap operasi. Penggunaan obat anestesi induksi mempunyai pengaruh menghambat agregasi trombosit. Propofol dan Penthotal mempengaruhi Agregasi Trombosit. Tujuan : Membuktikan perbedaan pengaruh Propofol dan Penthotal terhadap Agregasi Trombosit. Metode : Merupakan penelitian Randomized Clinical Control Trial pada 34 pasien yang menjalani anestesi umum, dibagi menjadi 2 kelompok (n=17), Propofol dan Penthotal. Masing-masing kelompok diperiksa TAT sebelum induksi dan 5 menit setelah induksi. Uji statistik pair t-test dan independent t-test terhadap propofol atau penthotal dan agregasi trombosit. Hasil : Agregasi maksimal trombosit, sebelum dan sesudah pemberian propofol atau penthotal berbeda bermakna. Kelompok penthotal persentase agregasi maksimal trombosit 68,73 ± 6,06% dan propofol 54,68 ± 9,55%, menunjukkan perbedaan yang bermakna antara keduanya (p=0,001). Hasil sesudah perlakuan, kelompok propofol 14 orang hipoagregasi (82,4%), dan 3 orang normoagregsi (17,6%). Sementara kelompok penthotal 5 orang hipoagregasi (29,4%), dan sisanya 12 orang normoagregasi (70,6%). Secara statistik propofol secara bermakna menyebabkan hipoagregasi daripada penthotal. Kesimpulan : Propofol secara bermakna menurunkan agregasi maksimal trombosit dan menyebabkan hipoagregasi lebih banyak daripada penthotal. Kata kunci : propofol, penthotal, ADP, agregasi trombosit