The influence of age factor upon the patients with radical cystectomy and prognosis analysis

Background and purpose:There are many prognostic factors on survival for the patients with radical cystectomy,whether age is an important factor or not,or should the elderly accept the operation are still in controversy.In this article we investigated the influence of age factor upon the patients with radical cystectomy,further to evaluate the usefulness of radical cystectomy for bladder cancer in elderly patients.Methods:We retrospectively analyzed the clinical and follow-up data of 121 patients with bladder cancer treated by radical cystectomy,analyzed the effects of age and other clinical or pathological characteristics for prognosis of the patients.Results:After radical cystectomy,the perioperative mortality of the elder group(≥70 years) is higher than those of the younger group(≤50 years or between 50 to 69 years) ,but there was no difference in terms of early postoperative complications among these groups.With the increase of age,the cancer specifi c survival of the patients with invasive bladder cancer was decreased,while for the patients with noninvasive bladder cancer,there was no difference.Multivariate and correlation analyses were performed and showed that there was close correlation between age and tumor stage,grade,size,lymph node metastasis and lymphovascular invasion.Conclusion:The treatment for the elder patients with bladder cancer by radical cystectomy is safe,the surgery could improve the survival rate of patients without increasing the postoperative complications.Age is an important prognostic factor but is not the most important.Tumor stage,grade and other poor prognosis factors play decisive roles.