Sensitivities of bleomycin-resistant variant cells enhanced by 40°C hyperthermia in vitro
1988
Cultured mammalian cells of higher (mouse L) and lower (Chinese hamster V-79) sensitivities to bleomycin (BLM) were repeatedly treated with BLM (0.1 mg/ml), through which BLM-resistant variant strains were induced. Sensitivities of these variant strains to BLM were enhanced by simultaneous treatment with 40°C hyperthermia.
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