ESSAI DU DOSAGE PAR SPECTROPHOTOMETRIE UV DU FUROSEMIDE VENDU A BUKAVU

Introduction: The rapid diuretic furosemide is the temporary loop that is used in the states of edema associated so far in the liver, kidney and heart especially by oral and intravenous routes of administration but its quality control remains a problem in the administration of this drug in the DR Congo. Method: A cross sectional study was performed on three brands of furosemide 40mg sold in pharmacies Gerva Foundation More and Biosadec of Bukavu in the South Kivu Province. A sample of 60 tablets in the newly approved three pharmacies or 20 tablets per drug were dissolved in water as a solvent and analyzed by UV spectrophotometry at 270 nm to determine the concentrations of active ingredients. The Anova test at significance level 0.5 and linear regression using the Past version1.9.1 and Excel 2010 were used to compare quantitative variables. Result: Three brands of furosemide (New cesamex Techno economic services Frusina) Frusina shows slightly high test percentage of 99.6% and the two other marks techno economic services and New cesamex show respectively a percentage of the testing of 98 , 75%. A non-significant difference was observed between the three brands p> 0.05 with R2 = 0.99.