Opioid Control of Gonadotropin Secretion

Among the various neuropeptides which regulate gonadotropin secretion, endogenous opioid peptides (EOP) play an important role. Substantial evidence suggests a possible key function of for these peptides in the control of female reproduction. Infertility, for example, is typical in members of both sexes who abuse opiates. The major target of EOP in regulating reproductive function is control of the secretion of luteinizing hormone (LH), inhibiting the activity of hypothalamic neurons which produce gonadotropin-releasing hormone (GnRH). A possible action of opioids on pituitary and/or gonadal hormone secretion has also been demonstrated.