Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

Yoshikazu Asahina,Nicholas R. Wurtz,Kazuto Arakawa,Nancy L. Carson,Kiyoshi Fujii,Kazunori Fukuchi,Ricardo Garcia,Mei-Yin Hsu,Junichi Ishiyama,Bruce R. Ito,Ellen K. Kick,John A. Lupisella,Shingo Matsushima,Kohei Ohata,Jacek Ostrowski,Yoshifumi Saito,Kosuke Tsuda,Francisco Villarreal,Hitomi Yamada,Toshikazu Yamaoka,Ruth R. Wexler,David A. Gordon,Yasuchi Kohno

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

2020

Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report ...

Keywords:

Biochemistry
Formyl peptide receptor 2
Pharmacology
Heart failure
Agonist
Inflammation
Chemistry

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