Construction of a recombinant duck enteritis virus (DEV) expressing hemagglutinin of H5N1 avian influenza virus based on an infectious clone of DEV vaccine strain and evaluation of its efficacy in ducks and chickens

Jichun Wang,Aimin Ge,Mengwei Xu,Zhisheng Wang,Yongfeng Qiao,Yiqi Gu,Chang Liu,Yamei Liu,Jibo Hou

Construction of a recombinant duck enteritis virus (DEV) expressing hemagglutinin of H5N1 avian influenza virus based on an infectious clone of DEV vaccine strain and evaluation of its efficacy in ducks and chickens

2015

Jichun Wang
Aimin Ge
Mengwei Xu
Zhisheng Wang
Yongfeng Qiao
Yiqi Gu
Chang Liu
Yamei Liu
Jibo Hou

Background Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine candidates.

Keywords:

Mardivirus
Viral replication
Influenza A virus subtype H5N1
Virology
Hemagglutination assay
Veterinary virology
Virus
Biology
Hemagglutinin (influenza)
H5N1 genetic structure
Influenza A virus
clone (Java method)

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