Age Is the Strongest Effector for the Relationship between Estimated Glomerular Filtration Rate and Coronary Artery Calcification in Apparently Healthy Korean Adults

Staging system with eGFR grade: stage 1, eGFR ≥90 mL/min/1.73 m 2 ; stage 2, eGFR 60 to 89 mL/min/1.73 m 2 ; and stage 3, eGFR 30 to 59 mL/min/1.73 m 2 . Results: The mean age of the participants was 41.4 years and the mean eGFR was 103.6±21.7 mL/min/1.73 m 2 . Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed a weakly negative but significant association with CACS in bivariate correlation analysis (r=–0.076, P<0.01). Mean CACS significantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC significantly increased from CKD stage 1 to 3. Although the odds ratio for CAC significantly increased from stage 1 to 3 after adjustment for confounding factors, this significance was reversed when age was included in the model. Conclusion: In early CKD, renal function negatively correlated with the degree of CAC in Korean subjects. Age was the strongest effector for this association.