Effects of pioglitazone and tumor necrosis factor-α on adiponectin receptor mRNA expression in 3T3-L1 adipocytes

The effects of pioglitazone (PIO) and tumor necrosis faetor-α(TNF-α) on two kinds of adiponectin receptor (AdipoR) mRNA expression were observed in 3T3-L1 adipocytes by RT-PCR.AdipoR mRNA expression was up-regulated during 3T3-L1 preadipocyte differentiation;PIO could increase the AdipoR mRNA level expressed in undifferentiated and differentiated 3T3-L1 adipocytes in a time-and dose-dependent manner,and TNF-αhad no influence on the expression of AdipoR mRNA.