Graphene Oxide Supported Liposomes as Red Emissive Theranostics for Phototriggered Tissue Visualization and Tumor Regression

Selective tissue visualization and localized tumor regression without affecting the surrounding healthy tissues is a critical concern in cancer nanomedicine. Importantly, the complete wrapping of flimsy matrix like liposome by multifunctional graphene oxide is an interesting engineering for nanomedicine design. Moreover, designing a safe and biodegradable nanohybrid with significant theranostic ability is in current need for targeted combined therapies. Here, we report a comprehensive results of in vivo tumor diagnosis and phototriggered tumor regression using a biodegradable red emissive nanotheranostic system viz., Graphene Oxide Flakes fortified Liposome (GOF-Lipo), functionalized with Folic Acid (FA); GOF-Lipo-FA. Graphene oxide support enhances the stability of drug loaded liposomes in extracellular environment that prevent the premature release of loaded anticancer drug from liposomal cavity. Promising outcomes of tumor regression (~ 300 to 25 mm3) from organized cellular and animal studies are demo...