Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds

Wallace T. Ashton,Laura C. Meurer,Cantone Cl,A K Field,John Hannah,John D. Karkas,Richard Liou,Gool F. Patel,Helen C. Perry,Arthur F. Wagner

Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds

1988

Wallace T. Ashton
Laura C. Meurer
Cantone Cl
A K Field
John Hannah
John D. Karkas
Richard Liou
Gool F. Patel
Helen C. Perry
Arthur F. Wagner

Cyclopropanation of acrylonitrile (I) with ethyl diazoacetate (II) gives the diastereomeric cyclopropanes (III) which are reduced, yielding the amino alcohols (IV).

Keywords:

Diastereomer
Guanine
Ethyl diazoacetate
Organic chemistry
Biochemistry
Bicyclic molecule
Acrylonitrile
Hydroxymethyl
Chemistry
Cyclopropanation
Polymerase
Enzyme
Biological activity
Thymidine kinase
DNA polymerase
Stereochemistry

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