Cerebral hypoperfusion in young transgenic APP mice predicts spatial distribution of amyloid deposition

Institutional Animal Care and Use Committee. Results: Some extent of ARIA-E was observed in 20/28 APP+PS1, and 0/10 of the WT littermates. The most common pattern was observed in the ventral regions of the piriform cortical lobe and the medial nucleus of the amygdala. Histological results showed albumin in the parenchyma in the anatomical region that had an MR-visible ARIA-E lesion. ARIA-H was observed in 21/28 APP+PS1 mice, and in 0/10 of the WT littermates. These were primarily in the dorsal half of the cortex, but several appeared in the cerebellum. Perls’ iron positive foci histologically colocalized with these MR-visible ARIA-H lesions. Conclusions: In summary, we have demonstrated MR imaging can detect spontaneously-occurring intensity alterations consistent with ARIA-E and AREA-H in aged Ab-bearing transgenic mice, with the APP+PS1 strain appearing to be most sensitive. The pathogenesis of these findings and their relevance toMR clinical observations are being evaluated in ongoing studies with therapies targeting Ab reduction.