Protective CD8 + T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

Katie J. Ewer,Geraldine A. O'Hara,Christopher J. A. Duncan,Katharine A. Collins,Susanne H. Sheehy,Arturo Reyes-Sandoval,Anna L. Goodman,Nick J. Edwards,Sean C. Elias,Fenella D. Halstead,Rhea J. Longley,Rosalind Rowland,Ian D. Poulton,Simon J. Draper,Andrew M. Blagborough,Eleanor Berrie,Sarah Moyle,Nicola Williams,Loredana Siani,Antonella Folgori,Stefano Colloca,Robert E. Sinden,Alison M. Lawrie,Riccardo Cortese,Sarah C. Gilbert,Alfredo Nicosia,Adrian V. S. Hill

Protective CD8 + T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

2013

Induction of protective immunity mediated by CD8+ T cells has been a long sought goal in vaccinology. Here, Ewer et al. report induction of protective efficacy against Plasmodium falciparum malaria in a phase IIa prime-boost vaccine trial where efficacy correlates strongly with induced CD8 T-cell responses.

Keywords:

Immunity
DNA vaccination
CD8
Cytotoxic T cell
Plasmodium falciparum
Vaccine trial
Interferon gamma
Malaria
Immunology
Virology
Biology

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