Rapid and robust speciation/quantitative analysis of arsenous acid and related metabolites in serum by liquid chromatography–inductively coupled plasma-tandem mass spectrometry

Purpose Arsenic, especially inorganic trivalent species, is one of the most important poisons in the field of forensic toxicology. There are many reports on the speciation analysis of arsenic species in biological specimens by liquid chromatography–inductively coupled plasma-mass spectrometry (LC–ICP-MS). The aim of this study was to develop a rapid and robust analytical method for speciation/quantitative analysis of arsenic species in serum by LC–ICP-tandem mass spectrometry (MS/MS).