Effects of Dietary Nucleotides on Hepatic Fibrosis Induced by CCl_4 Injection in Rat

Objective Effects of dietary nucleotides on hepatic fibrosis induced by CCl_4 were studied.Methods 90 SD rats were divided randomly into a control group,a CCl_4 group and a CCl_4 + NTs group.Rats in CCl_4 group and CCl_4 + NTs group got abdominal injection of CCl_4 2 times a week for 12 weeks, the CCl_4 + NTs group was fed with a nucleotide-supplemented diet,the control group and the CCl_4 group were fed with a nucleotide-free diet.Results The survival rate of CCl_4 + NTs group rats is 93%and the CCl_4 group is only 80%.The rats weight of the CCl_4 group is lighter than the CCl_4 + NTs group,and markedly in the 2nd,4th,6th,8th and 10th week.The rats weight of the CCl_4 + NTs group is also lighter than the control group,but not markedly.In the CCl_4 group,the content of MDA in liver homogenate higher than the CCl_4 + NTs group and control group.And the morphologic features of rat liver shows the NTs group have a milder liver injury.Conclusion Dietary Nucleotides may interfere the hepatic fibrosis induced by CCl_4 in rat.