Direct observation of DNA motion near a nanopore

Nanopore devices have made great progress toward a direct reading method for DNA sequences. However, relatively long DNA’s, i.e. lambda or T4, frequently clog at a pore. We have focused on visualizing DNA molecules near nanopores and investigated the dynamics using fluorescence microscopy. Various length and form, linear or circular of DNA molecules were used to quantify the clogging phenomenon. In the presentation, we will discuss the details with the numerical simulation.