Circular RNA and its application in gynecological carcinoma

Circular RNAs (circRNAs) are a class of RNA which forms covalently closed loops. They act as microRNA (miRNA) sponge in the circRNA-miRNA-mRNA regulatory axis, regulating gene transcription and protein translation. CircRNAs are differently expressed in gynecological carcinoma. They can affect the proliferation, invasion and migration of gynecological tumor cells, playing a role in inhibiting or promoting cancer. CircRNAs are featured with characteristics of stabilities, abundance, specificity and conservative, making it a potential target for the prediction, diagnosis and treatment of gynecologic tumors. Key words: MicroRNAs; Genital neoplasms, female; Gene expression regulation; Circular RNA