TOTAL SYNTHESIS OF THE THYMIDINE ANALOGUE OF SINEFUNGIN

Abstract The carbon skeleton of “Sinethymidin” 4 was constructed by two radical coupling reaction. The first step was a coupling of the radical derived from 2 and the unsaturated amide 5. The olefin 6 thus obtained was added to the radical derived from the known N-hydroxy-2-thiopyridinone aspartic ester. “Sinethymidin”, tested for its antileismanial effect, was devoid of activity.