Occupational asthma caused by heated triglycidyl isocyanurate

Six workers exposed as bystanders to heated triglycidyl isocyanurate (TGIC) developed occupational asthma confirmed by serial peak expiratory flow measurement and Oasys analysis. Specific inhalation challenge testing resulted in late or dual asthmatic reactions to heated TGIC in four of four tested and was negative in three control asthmatics. One worker tested only with unheated TGIC had a negative specific challenge test. Heated TGIC can cause occupational asthma from bystander exposure.