Intranodal Sirolimus Induces Regulatory T Cells in Human Hepatic Lymph Nodes via Interleukin 10 Signaling.

Many transplant recipients die with functional transplant grafts. Immune-related morbidity and mortality due to conventional systemic immunosuppression continue being the major barrier against long-term success of solid organ transplantation including liver transplantation (LT). Targeted immunotherapy is urgently needed.