Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response.

Juan Antonio García-León,Carlos López-Gómez,Teresa Órpez-Zafra,Virginia Reyes-Garrido,Carmen Marín-Bañasco,Begoña Oliver-Martos,Oscar Fernández,Laura Leyva

Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response.

2014

Juan Antonio García-León
Carlos López-Gómez
Teresa Órpez-Zafra
Virginia Reyes-Garrido
Carmen Marín-Bañasco
Begoña Oliver-Martos
Oscar Fernández
Laura Leyva

Background Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and inhibitory isoforms.

Keywords:

Lymphocyte
Multiple sclerosis
Innate immune system
Immune system
Natural killer cell
Killer-cell immunoglobulin-like receptor
Interferon
Receptor
Biology
Immunology
Gene isoform
Biomarker (medicine)
Medicine

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