Thermo-Sensitive Nanogated System Based on Polymer-Modified Mesoporous Silica Hybrid Nanoparticles

Mesoporous silica nanoparticles (MSNs) have been employed as a versatile solid support for constructing a variety of hybrid materials for controlled drug delivery. Controlled release systems that integrate external stimuli with nanocarriers have attracted much attention for sensors and drug delivery applications. Mesoporous silica nanoparticles grafted with thermo-sensitive polymers on the surface were fabricated via “grafting to” approach through chemical coupling reaction. The encapsulation and release of drug based on the thermo-sensitive nanogated system were investigated. The thermo-sensitive nanogated system can be expected as one of the promising candidates for drug delivery and controlled release.