W1938 Methylation Chip Assay for Determination of Gastric Cancer Associated CpG Island Methylated Gene

zone, a specific PPARγ agonist, increased gastrin gene expression and Bcl-2 and PKB/Akt protein levels in each of cancer cell lines examined. Furthermore, transfection of the PANC1, HT29 and HCT116 cells with a PPARγ siRNA reversed ciglitazone-induced PKB/Akt phosphorylation and Bcl-2 protein up-regulation. Conclusions: 1) Gastrin peptide promotes cancer cells growth via an increase in annexin II cell surface concentration in these cells; 2) gastrin cooperates with the tumour-growth promoting activity of PPARγ agonists.