Mangiferin cream with anti-herpes simplex virus effect

The invention discloses an external cream preparation for effectively treating herpes simplex virus (HSV) I type and II type infectious diseases and a preparation method as well as application thereof. The cream is prepared from high-purity mangiferin (purity of greater than or equal to 90 percent) serving as a raw material and proper auxiliary materials, wherein the mangiferin raw material is treated by using a micronization technique. Experiments prove that the cream has a good anti-herpes simplex virus effect, fast response and obviously shortened recovery time after the mangiferin raw material is micronized. The preparation method for the mangiferin cream is simple and convenient, and can be easily promoted to industrial large-scale production. Anti-herpes simplex virus pharmaceutical effect evaluation experiments and clinical pretests prove that the mangiferin cream has good curative effect on treatment of HSV-1 and HSV-2 infection, high safety and no toxic and side effects.