Mycosis fungoides with focal segmental glomerular sclerosis and nephrotic syndrome

Abstract Cutaneous T-cell lymphoma includes mycosis fungoides and the leukemic variant, Sezary syndrome. We report the first two cases of focal segmental glomerulosclerosis in patients with cutaneous T-cell lymphoma, with nephrotic range proteinuria and review the literature on renal disease coexisting with cutaneous T-cell lymphoma. We hypothesize that glomerular injury in cutaneous T-cell lymphoma may be related to interleukin-2. (J Am Acad Dermatol 1998;38:301-5.)