Plasma-mediated leukemia cell destruction: concentration and purification of the antileukemia factor.

SummarySelective destruction of leu-kemic cells has been observed in AKR mice following infusion of normal serum, plasma, or whole blood. Heparinized plasma has significantly greater antileukemia activity than serum, and the active factor can be concentrated and purified by heparin precipitation or adsorption onto a calcium phosphate gel.