Glycerol/fructose composite and preparation method thereof

The invention relates to a glycerol/fructose composite characterized in that the composite in preparation consumption by 1,000 bottles comprises the following components by weight part: 25kg of glycerol, 12.5kg of fructose, 2.25kg of sodium chloride and water for injection added to 250,000ml. The preparation method comprises the following steps: (1) weighing the glycerol, fructose and sodium chloride according to the formula, and placing in a proper sterile container; (2) adding the water for injection, and stirring to dissolve the components; (3) adding 0.08% active carbon for needles, stirring, keep boiling gently (100 DEG C) for 15min, and immediately decarburizing and filtering with a titanium filter rod; (4) further adding the water for injection to the required amount, adjusting the pH value to 3.0 to 6.0 by the 0.1mol/L hydrochloric acid solution, filtering with a phi 0.22mum microporous membrane and a phi 0.45mum microporous membrane, and determining (the content and pH value of) the intermediates; (5) filling and capping after the intermediates are determined to be qualified; and (6) sterilizing at high temperature. The product of the invention achieves the effect of effectively reducing the intracranial pressure, has long duration and avoids the rebound; meanwhile, the urine volume thereof is obviously lower than that of patients to whom mannitol is administered, thus reducing the load of the kidney; and the product can further provide the patients with certain energy. Therefore, the glycerol/fructose composite is particularly suitable for patients in long-term coma.