PO030 Combining informant (ad8) and patient (mace) cognitive screening

Objective To assess the combination of informant questionnaire AD8 and the Mini-Addenbrooke’s Cognitive Examination (MACE) for diagnosis of dementia and cognitive impairment (MCI) in a cognitive disorders clinic. The current standard of formal cognitive assessment is unwieldy in a busy out-patient setting and thus more efficient methods of clinical evaluation with retained diagnostic accuracy are desirable. Results Of 67 patient-informant dyads seen over 8 months (May-December 2016; F:M=33:34, 49% female; age range 26–88 years, median 64), 14 patients were diagnosed with dementia (DSM-IV-TR criteria), 32 with MCI (Petersen criteria). Using cutoffs defined in index studies (AD8 ≥2/8; MACE≤25/30), both instruments were very sensitive (>0.9) but not specific ( 0.7 for all combinations, with predictive summary index marginally better for parallel combination. Conclusion The results of this pragmatic study suggest that series combination of an informant (AD8) and patient (MACE) cognitive screening instrument may improve diagnostic specificity compared to individual use of tests.